Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism

• Main Authors: Deepti Abbey (Author), Donna Conlon (Author), Christopher Rainville (Author), Susannah Elwyn (Author), Katherine Quiroz‐Figueroa (Author), Jeffrey Billheimer (Author), David C. Schultz (Author), Nicholas J. Hand (Author), Sara Cherry (Author), Daniel J. Rader (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis are needed. We performed a siRNA kinase and phosphatase screen in HuH‐7 cells usi...