Modulators of HIF1a and NFkB in Cancer treatment: Is it a rational approach for controlling malignant progression?

• Main Authors: Marco eTafani (Author), Bruna ePucci (Author), Andrea eRusso (Author), Luana eSchito (Author), Laura ePellegrini (Author), Giulietta A Perrone (Author), Lidia eVillanova (Author), Luisa eSalvatori (Author), Linda eRavenna (Author), Elisa ePetrangeli (Author), Matteo A Russo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIF1 and NFkB are two transcription factors very frequently activated in tumors and involved in tumor growth, progression and resistance to chemotherapy. In fact, HIF1 and NFkB together regulate transcription of over a thousand genes that, in turn, control vital cellular processes such as adaptati...