Suppression of endoplasmic reticulum stress-dependent autophagy enhances cynaropicrin-induced apoptosis via attenuation of the P62/Keap1/Nrf2 pathways in neuroblastoma

• Main Authors: Randong Yang (Author), Shurong Ma (Author), Ran Zhuo (Author), Lingqi Xu (Author), Siqi Jia (Author), Pengcheng Yang (Author), Ye Yao (Author), Haibo Cao (Author), Liya Ma (Author), Jian Pan (Author), Jian Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Autophagy has dual roles in cancer, resulting in cellular adaptation to promote either cell survival or cell death. Modulating autophagy can enhance the cytotoxicity of many chemotherapeutic and targeted drugs and is increasingly considered to be a promising cancer treatment approach. Cynaropicrin (...