The build-up of stock of stable integrated proviruses overtime explains the difficulty in reducing HIV-1 DNA levels when treatment is initiated at the chronic stage of the infection

• Main Authors: Gilbert Mchantaf (Author), Antoine Cheret (Author), Adeline Melard (Author), Asma Essat (Author), Elise Gardiennet (Author), Rebecca Bauer (Author), Caroline Charre (Author), Vincent Meiffredy (Author), Lionel Piroth (Author), Cécile Goujard (Author), Laurence Meyer (Author), Véronique Avettand-Fenoel (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Understanding factors affecting the size and the evolution of the HIV reservoir is essential for the development of curative strategies. This study aimed to assess the impact of antiretroviral therapy (ART) initiated during primary infection (PHI) vs chronic infection (CHI) on the levels...