Acute Oxidative Stress Can Paradoxically Suppress Human NRF2 Protein Synthesis by Inhibiting Global Protein Translation

• Main Authors: Kaitlin M. Pensabene (Author), Joseph LaMorte (Author), Amanda E. Allender (Author), Janessa Wehr (Author), Prabhjot Kaur (Author), Matthew Savage (Author), Aimee L. Eggler (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The NRF2 transcription factor is a master regulator of the cellular oxidant/electrophile response and a drug target for the prevention/treatment of chronic diseases. A major mechanism of NRF2 activation is its escape from rapid degradation, and newly synthesized NRF2 induces cytoprotective protein e...