Mesoporous silica nanoparticles with chiral pattern topological structure function as "antiskid tires" on the intestinal mucosa to facilitate oral drugs delivery

• Main Authors: Wei Xin (Author), Lin Wang (Author), Jiahui Lin (Author), Yanbu Wang (Author), Qi pan (Author), Yang Han (Author), Zhiye Bao (Author), Shun Zong (Author), Ying Cheng (Author), Xuchun Chen (Author), Lin Zhao (Author), Heran Li (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The weak adhesion between nanocarriers and the intestinal mucosa was one of the main reasons caused the failure in oral delivery. Inspired by the "antiskid tires" with complex chiral patterns, mesoporous silica nanoparticles AT-R@CMSN exhibiting geometrical chiral structure were designed t...