LC-MS/MS assay for olanzapine in human plasma and its application to a bioequivalence study

• Main Authors: Dinesh S. Patel (Author), Naveen Sharma (Author), Mukesh C. Patel (Author), Bhavin N. Patel (Author), Pranav S. Shrivastav (Author), Mallika Sanyal (Author)
• Format: Book
• Published: Elsevier, 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This paper describes a selective and sensitive assay for the determination of olanzapine (OLZ) in human plasma based on liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analyte and quetiapine as internal standard (IS) were extracted from 200 μL plasma via solid phase extraction on Wate...