The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

• Main Authors: Ravikumar A. Sitapara (Author), Alex G. Gauthier (Author), Sergio I. Valdés-Ferrer (Author), Mosi Lin (Author), Vivek Patel (Author), Mao Wang (Author), Ashley T. Martino (Author), Jeanette C. Perron (Author), Charles R. Ashby (Author), Kevin J. Tracey (Author), Valentin A. Pavlov (Author), Lin L. Mantell (Author)
• Format: Book
• Published: BMC, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia results in acute lung injury (ALI) and accumulation...