Physicochemical and biopharmaceutical characterization of new sulfonamide derivatives of gallic acid

• Main Authors: Dania Hussein Alhyari (Author), Helen Sheldrake (Author), Sriharsha Kantamneni (Author), Mohammad Isreb (Author), Shohreh Jafarinejad Soumehsaraei (Author), William Martin (Author), Nidal Qinna (Author), Krzysztof Paluch (Author)
• Format: Book
• Published: University of Huddersfield Press, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gallic acid (GA) is known for its antioxidant activity which is restricted due to its low oral permeability. In this project the carboxylic group of (GA) was substituted with sulfonamide group and hydroxyl groups were methylated which resulted insignificantly (p<0.01) increased permeability of 3,...