Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence

• Main Authors: Ju Chen (Author), Bhaskara Reddy Madina (Author), Elham Ahmadi (Author), Timur Olegovich Yarovinsky (Author), Marie Marthe Krady (Author), Eileen Victoria Meehan (Author), Isabella China Wang (Author), Xiaoyang Ye (Author), Elise Pitmon (Author), Xian-Yong Ma (Author), Bijan Almassian (Author), Valerian Nakaar (Author), Kepeng Wang (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for humans. Here, we describe the application of virus-like vesicles (VLV) for delivery of three immunomodulators alone and in combination, as a promising approach for cancer immunotherapy....