Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats

Hepatic clearance (CLh) of carvedilol (CAR), which is eliminated via stereoselective metabolism by the CYP2D subfamily of cytochromes P450 (CYPs), was predicted using liver microsomes and hepatocytes from Sprague-Dawley (SD) rats and CYP2D-deficient Dark Agouti (DA) rats to determine the usefulness...

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Main Authors: Masahiro Iwaki (Author), Toshiro Niwa (Author), Hiroyuki Tanaka (Author), Atsushi Kawase (Author), Hiroshi Komura (Author)
Format: Book
Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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