Early Cytokine-Induced Transient NOX2 Activity Is ER Stress-Dependent and Impacts β-Cell Function and Survival

• Main Authors: Eloisa A. Vilas-Boas (Author), Christopher Carlein (Author), Lisa Nalbach (Author), Davidson C. Almeida (Author), Emmanuel Ampofo (Author), Angelo R. Carpinelli (Author), Leticia P. Roma (Author), Fernanda Ortis (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In type 1 diabetes (T1D) development, proinflammatory cytokines (PIC) released by immune cells lead to increased reactive oxygen species (ROS) production in β-cells. Nonetheless, the temporality of the events triggered and the role of different ROS sources remain unclear. Isolated islets from C57BL/...