Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress

• Prif Awduron: Meghan Gage (Awdur), Marson Putra (Awdur), Logan Wachter (Awdur), Kylie Dishman (Awdur), Megan Gard (Awdur), Crystal Gomez-Estrada (Awdur), Thimmasettappa Thippeswamy (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2021-12-01T00:00:00Z.
• Pynciau: article
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Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective effects of saracatinib (AZD0530), a Src kinase inhibitor, in mixed-sex or male-only Sprague Dawley rats exposed to 4-5 mg/kg D...