Sildenafil affects the human Kir2.1 and Kir2.2 channels at clinically relevant concentrations: Inhibition potentiated by low Ba2+

• Main Authors: Akimasa Iijima (Author), Olga Švecová (Author), Jan Hošek (Author), Roman Kula (Author), Markéta Bébarová (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Sildenafil (Viagra), the first approved and widely used oral drug for the treatment of erectile dysfunction, was occasionally associated with life-threatening ventricular arrhythmias in patients. Since inward rectifier potassium current (IK1) may considerably contribute to this arrhythmogenesis, we...