Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma

• Main Authors: Mundanattu Swetha (Author), Chenicheri K. Keerthana (Author), Tennyson P. Rayginia (Author), Lekshmi R. Nath (Author), Nair Hariprasad Haritha (Author), Anwar Shabna (Author), Kalishwaralal Kalimuthu (Author), Arun K. Thangarasu (Author), Sreekumar U. Aiswarya (Author), Somaraj Jannet (Author), Sreekumar Pillai (Author), Kuzhuvelil B. Harikumar (Author), Sankar Sundaram (Author), Nikhil Ponnoor Anto (Author), Dee H. Wu (Author), Ravi S. Lankalapalli (Author), Rheal Towner (Author), Noah Isakov (Author), Sathyaseelan S. Deepa (Author), Ruby John Anto (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously reported the remarkable potency of uttroside B (Utt-B), saponin-isolated and characterized in our lab from <i>Solanum nigrum</i> Linn, against HCC. Recently, the U.S. FDA approved Utt-B as an 'orphan drug' against HCC. The current study validates the superior anti...