Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer

• Main Authors: Sachin Sharma (Author), Kavya Chandra (Author), Aliva Naik (Author), Anamika Sharma (Author), Ram Sharma (Author), Amandeep Thakur (Author), Ajmer Singh Grewal (Author), Ashwani K. Dhingra (Author), Arnab Banerjee (Author), Jing Ping Liou (Author), Santosh Kumar Guru (Author), Kunal Nepali (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Structural tailoring of the flavone framework (position 7) via organopalladium-catalyzed C-C bond formation was attempted in this study. The impact of substituents with varied electronic effects (phenyl ring, position 2 of the benzopyran scaffold) on the antitumor properties was also assessed. Resul...