Determination of Tissue Distribution of Alisol G, a CB1R Antagonist, in Rats by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry

• Prif Awduron: Chen-Yu Gao (Awdur), Jian-Qiang Xi (Awdur), Ding-Zhong Song (Awdur), Jie Yuan (Awdur), Wu-Si Hao (Awdur), Zhong-Bao Cui (Awdur), Zhi-Hong Cheng (Awdur)
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• Cyhoeddwyd: Georg Thieme Verlag KG, 2020-12-01T00:00:00Z.
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Peripheral CB1R blockers without crossing the blood-brain barrier (BBB) have demonstrated therapeutic benefits in metabolic syndromes, including obesity. Among them is Alisol G, a tetracyclic triterpene from Alismatis rhizoma (zexie), which can effectively reduce the weight of obese mice. Results fr...