Determination of Tissue Distribution of Alisol G, a CB1R Antagonist, in Rats by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry

• Main Authors: Chen-Yu Gao (Author), Jian-Qiang Xi (Author), Ding-Zhong Song (Author), Jie Yuan (Author), Wu-Si Hao (Author), Zhong-Bao Cui (Author), Zhi-Hong Cheng (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peripheral CB1R blockers without crossing the blood-brain barrier (BBB) have demonstrated therapeutic benefits in metabolic syndromes, including obesity. Among them is Alisol G, a tetracyclic triterpene from Alismatis rhizoma (zexie), which can effectively reduce the weight of obese mice. Results fr...