Cu²⁺-Chelating Mesoporous Silica Nanoparticles for Synergistic Chemotherapy/Chemodynamic Therapy

• Asıl Yazarlar: Yanyan Zhang (Yazar), Jiadong Lou (Yazar), Gareth R. Williams (Yazar), Yuhan Ye (Yazar), Dandan Ren (Yazar), Anhua Shi (Yazar), Junzi Wu (Yazar), Wenling Chen (Yazar), Li-Min Zhu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

In this study, a pH-responsive controlled-release mesoporous silica nanoparticle (MSN) formulation was developed. The MSNs were functionalized with a histidine (His)-tagged targeting peptide (B3int) through an amide bond, and loaded with an anticancer drug (cisplatin (CP)) and a lysosomal destabiliz...