Cu²⁺-Chelating Mesoporous Silica Nanoparticles for Synergistic Chemotherapy/Chemodynamic Therapy

• Main Authors: Yanyan Zhang (Author), Jiadong Lou (Author), Gareth R. Williams (Author), Yuhan Ye (Author), Dandan Ren (Author), Anhua Shi (Author), Junzi Wu (Author), Wenling Chen (Author), Li-Min Zhu (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, a pH-responsive controlled-release mesoporous silica nanoparticle (MSN) formulation was developed. The MSNs were functionalized with a histidine (His)-tagged targeting peptide (B3int) through an amide bond, and loaded with an anticancer drug (cisplatin (CP)) and a lysosomal destabiliz...