Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay

In vitro evaluation of P-glycoprotein (P-gp) inhibitory potential is now a regulatory issue during drug development, in order to predict clinical inhibition of P-gp and subsequent drug-drug interactions. Assays for this purpose, commonly based on P-gp-expressing cell lines and digoxin as a reference...

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Hoofdauteurs: Elodie Jouan (Auteur), Marc Le Vée (Auteur), Abdullah Mayati (Auteur), Claire Denizot (Auteur), Yannick Parmentier (Auteur), Olivier Fardel (Auteur)
Formaat: Boek
Gepubliceerd in: MDPI AG, 2016-04-01T00:00:00Z.
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