Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay

• Main Authors: Elodie Jouan (Author), Marc Le Vée (Author), Abdullah Mayati (Author), Claire Denizot (Author), Yannick Parmentier (Author), Olivier Fardel (Author)
• Format: Book
• Published: MDPI AG, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In vitro evaluation of P-glycoprotein (P-gp) inhibitory potential is now a regulatory issue during drug development, in order to predict clinical inhibition of P-gp and subsequent drug-drug interactions. Assays for this purpose, commonly based on P-gp-expressing cell lines and digoxin as a reference...