Analysis of original bis-arylazaazkanes derivatives compliance with the calculated pharmacophoric models of biaromatic ligands of cardioprotective drugs biotargets

• Main Authors: G. V. Mokrov (Author), A. S. Pantileev (Author), T. Yu. Vorobieva (Author), V. E. Biryukova (Author), S. A. Kryzhanovskii (Author), V. L. Dorofeev (Author)
• Format: Book
• Published: LLC "Publisher OKI", 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Eight important biotargets of biaromatic cardioprotective drugs were selected in this work: calcium Cav1.2-channel, sodium Nav1.5-channel, potassium hERG-channel and Kv1.5-channel, HCN-channel, β1-adrenergic receptor, ryanodine RyR2-receptor and σ1-receptor. Biaromatic ligands databases were collect...