Itraconazole Reverts ABCB1-Mediated Docetaxel Resistance in Prostate Cancer

• Main Authors: Thiago S. Lima (Author), Luciano O. Souza (Author), Diego Iglesias-Gato (Author), Johanna Elversang (Author), Flemming Steen Jørgensen (Author), Tuula Kallunki (Author), Martin A. Røder (Author), Klaus Brasso (Author), José M.A. Moreira (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Docetaxel (DTX) was the first chemotherapeutic agent to demonstrate significant efficacy in the treatment of men with metastatic castration-resistant prostate cancer. However, response to DTX is generally short-lived, and relapse eventually occurs due to emergence of drug-resistance. We previously e...