Proof‐of‐concept for incorporating mechanistic insights from multi‐omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae

• Main Authors: Patrick O. Hanafin (Author), Nusaibah Abdul Rahim (Author), Rajnikant Sharma (Author), Colin G. Cess (Author), Stacey D. Finley (Author), Phillip J. Bergen (Author), Tony Velkov (Author), Jian Li (Author), Gauri G. Rao (Author)
• Format: Book
• Published: Wiley, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Carbapenemase‐resistant Klebsiella pneumoniae (KP) resistant to multiple antibiotic classes necessitates optimized combination therapy. Our objective is to build a workflow leveraging omics and bacterial count data to identify antibiotic mechanisms that can be used to design and optimize co...