A High-Affinity ⁶⁴Cu-Labeled Ligand for PET Imaging of Hepsin: Design, Synthesis, and Characterization

• Principais autores: Ji-Hun Park (Autor), Xuran Zhang (Autor), Hyunsoo Ha (Autor), Jung Young Kim (Autor), Joon Young Choi (Autor), Kyung-Han Lee (Autor), Youngjoo Byun (Autor), Yearn Seong Choe (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Hepsin, a cell surface serine protease, is a potential biomarker for the detection of prostate cancer due to its high expression in prostate cancer but not in normal prostate. This study aimed to develop a radioligand for positron emission tomography (PET) imaging of hepsin. Six leucine-arginine (Le...