A High-Affinity ⁶⁴Cu-Labeled Ligand for PET Imaging of Hepsin: Design, Synthesis, and Characterization

• Main Authors: Ji-Hun Park (Author), Xuran Zhang (Author), Hyunsoo Ha (Author), Jung Young Kim (Author), Joon Young Choi (Author), Kyung-Han Lee (Author), Youngjoo Byun (Author), Yearn Seong Choe (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepsin, a cell surface serine protease, is a potential biomarker for the detection of prostate cancer due to its high expression in prostate cancer but not in normal prostate. This study aimed to develop a radioligand for positron emission tomography (PET) imaging of hepsin. Six leucine-arginine (Le...