Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice

• Main Authors: Kimberly K. Richardson (Author), Gareeballah Osman Adam (Author), Wen Ling (Author), Aaron Warren (Author), Adriana Marques-Carvalho (Author), Jeff D. Thostenson (Author), Kimberly Krager (Author), Nukhet Aykin-Burns (Author), Stephanie D. Byrum (Author), Maria Almeida (Author), Ha-Neui Kim (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The mitochondrial deacetylase sirtuin-3 (SIRT3) is necessary for the increased bone resorption and enhanced function of mitochondria in osteoclasts that occur with advancing age; how SIRT3 drives bone resorption remains elusive. Methods: To determine the role of SIRT3 in osteoclast mitoc...