Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice

• Главные авторы: Kimberly K. Richardson (Автор), Gareeballah Osman Adam (Автор), Wen Ling (Автор), Aaron Warren (Автор), Adriana Marques-Carvalho (Автор), Jeff D. Thostenson (Автор), Kimberly Krager (Автор), Nukhet Aykin-Burns (Автор), Stephanie D. Byrum (Автор), Maria Almeida (Автор), Ha-Neui Kim (Автор)
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• Опубликовано: Elsevier, 2024-10-01T00:00:00Z.
• Предметы: article
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Objectives: The mitochondrial deacetylase sirtuin-3 (SIRT3) is necessary for the increased bone resorption and enhanced function of mitochondria in osteoclasts that occur with advancing age; how SIRT3 drives bone resorption remains elusive. Methods: To determine the role of SIRT3 in osteoclast mitoc...