Cover Image

Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice

Objectives: The mitochondrial deacetylase sirtuin-3 (SIRT3) is necessary for the increased bone resorption and enhanced function of mitochondria in osteoclasts that occur with advancing age; how SIRT3 drives bone resorption remains elusive. Methods: To determine the role of SIRT3 in osteoclast mitoc...

Full description

Saved in:

Bibliographic Details
Main Authors:	Kimberly K. Richardson (Author), Gareeballah Osman Adam (Author), Wen Ling (Author), Aaron Warren (Author), Adriana Marques-Carvalho (Author), Jeff D. Thostenson (Author), Kimberly Krager (Author), Nukhet Aykin-Burns (Author), Stephanie D. Byrum (Author), Maria Almeida (Author), Ha-Neui Kim (Author)
Format:	Book
Published:	Elsevier, 2024-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

PCB11 Metabolite, 3,3'-Dichlorobiphenyl-4-ol, Exposure Alters the Expression of Genes Governing Fatty Acid Metabolism in the Absence of Functional Sirtuin 3: Examining the Contribution of MnSOD
by: Sinthia Alam, et al.
Published: (2018)

Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans)
by: Ujwani Nukala, et al.
Published: (2018)

SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1
by: Rajaa Sebaa, et al.
Published: (2019)

Modulation of Radiation Response by the Tetrahydrobiopterin Pathway
by: Rupak Pathak, et al.
Published: (2015)

SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging
by: Yong Lan, et al.
Published: (2021)

SIRT1-mediated deacetylation of FOXO3 enhances mitophagy and drives hormone resistance in endometrial cancer
by: Xuehua Wei, et al.
Published: (2024)

The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
by: Francesca V. LoBianco, et al.
Published: (2020)

Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation
by: Yongjun Yang, et al.
Published: (2024)

The Immunologic Relationship between Root Resorptions and Osteoclastic Activity - Literature Review
by: Luciano Silva, et al.
Published: (2016)

Effects of Erythromycin on Osteoclasts and Bone Resorption via DEL-1 Induction in Mice
by: Hikaru Tamura, et al.
Published: (2021)

Mechanisms of promoting the differentiation and bone resorption function of osteoclasts by Staphylococcus aureus infection
by: Zelei Tong, et al.
Published: (2022)

SIRT2-dependent DKK1 deacetylation aggravates polycystic ovary syndrome by targeting the TGF-β1/Smad3 signaling pathway
by: Lan Chen, et al.
Published: (2024)

Analysis of Osteoclasts and Root Resorption in Corticotomy-Facilitated Orthodontics with Ibuprofen Administration-An Animal Study
by: Chanakant Jindarojanakul, et al.
Published: (2022)

Aminooxyacetic acid hemihydrochloride inhibits osteoclast differentiation and bone resorption by attenuating oxidative phosphorylation
by: Biao Yang, et al.
Published: (2022)

3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice
by: Tai-yong Yu, et al.
Published: (2015)

MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21
by: Yiqiang Sun, et al.
Published: (2021)

Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1α-Sirt1 Pathway
by: Min-Yen Hsu, et al.
Published: (2021)

Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects
by: Stephen A. Shrum, et al.
Published: (2023)

Shen Shuai IIRecipe attenuates renal injury and fibrosis in chronic kidney disease by regulating NLRP3 inflammasome and Sirt1/Smad3 deacetylation pathway
by: Meng Wang, et al.
Published: (2019)

Evaluation of the effects of two different bone resorption inhibitors on osteoclast numbers and activity: An animal study
by: Narges Naghsh, et al.
Published: (2016)

Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit
by: Wang X, et al.
Published: (2018)

Retraction Notice to: MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21
by: Yiqiang Sun, et al.
Published: (2022)

ANXA1sp Protects against Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death via SIRT3-Mediated p53 Deacetylation
by: Song Qin, et al.
Published: (2023)

Degrees of chitosan deacetylation from white shrimp shell waste as dental biomaterials
by: Sularsih Sularsih, et al.
Published: (2012)

Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1β expression
by: Han Saem Son, et al.
Published: (2020)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity
by: Jianbo He, et al.
Published: (2021)

Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo
by: Sun P, et al.
Published: (2020)

The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption
by: Sachin Wani, et al.
Published: (2022)

Corrigendum: Inhibitory effects of Rhaponticin on osteoclast formation and resorption by targeting RANKL-induced NFATc1 and ROS activity
by: Jianbo He, et al.
Published: (2023)

The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption
by: Xuqiang Liu, et al.
Published: (2017)

The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats
by: Wenhao Zheng, et al.
Published: (2024)

Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-κB Pathways
by: Kaiqiang Sun, et al.
Published: (2022)

Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function
by: Bugga Paramesha, et al.
Published: (2021)

SIRT3 Modulates Endothelial Mitochondrial Redox State during Insulin Resistance
by: Elisa Martino, et al.
Published: (2022)

Synthesis of Fully Deacetylated Quaternized Chitosan with Enhanced Antimicrobial Activity and Low Cytotoxicity
by: Yeon Ho Kim, et al.
Published: (2022)

Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells
by: Huihui Xu, et al.
Published: (2016)

Effects of degree of deacetylation and molecular weight of chitosan and bead preparation on the controlled drug release
by: Krisana Siraleartmukul
Published: (2007)

Research advances of SIRT3-mediated mitochondrial homeostasis in acute kidney injury
by: Peng-yan Li, et al.
Published: (2024)

Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro
by: Chuandong Wang, et al.
Published: (2017)

Natural Antioxidant Control of Neuropathic Pain-Exploring the Role of Mitochondrial SIRT3 Pathway
by: Sara Ilari, et al.
Published: (2020)