Human Neutrophil Defensins Disrupt Liver Interendothelial Junctions and Aggravate Sepsis

• Main Authors: QiXing Chen (Author), Yang Yang (Author), YiHang Pan (Author), LiHua Shen (Author), Yan Zhang (Author), Fei Zheng (Author), Qiang Shu (Author), XiangMing Fang (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human neutrophil peptides 1-3 (HNP1-3), also known as human α-defensins, are the most abundant neutrophil granule proteins. The genes that encode HNP1-3, DEFA1/DEFA3, exhibit extensive copy number variations, which correlate well with their protein levels. Human and mouse studies have shown that inc...