Dual-target anti-Alzheimer's disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity

• Main Authors: Zhisheng Mi (Author), Bing Gan (Author), Sihang Yu (Author), Jianan Guo (Author), Changjun Zhang (Author), Xiaoying Jiang (Author), Tao Zhou (Author), Jing Su (Author), Renren Bai (Author), Yuanyuan Xie (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MAO-B leads to an increase in the levels of hydrogen peroxide and oxidative free radicals, which contribute to the aetiology of the AD. Thus, both iron ion chelators and MAO-B inhibitors can be used to treat AD. Taking the coumarin derivatives and hydroxypyridinones as the lead compounds, a series o...