Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa

• Asıl Yazarlar: Cia-Hin Lau (Yazar), Jonathan Weng-Thim Ho (Yazar), Pik Kwan Lo (Yazar), Chung Tin (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2019-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Targeted transcriptional modulation in the central nervous system (CNS) can be achieved by adeno-associated virus (AAV) delivery of CRISPR activation (CRISPRa) and interference (CRISPRi) transgenes. To enable AAV packaging, we constructed minimal CRISPRa and CRISPRi transgenes by fusing catalyticall...