Deamidation-related blood biomarkers show promise for early diagnostics of neurodegeneration

• Main Authors: Jijing Wang (Author), Ya-Ru Zhang (Author), Xue-Ning Shen (Author), Jinming Han (Author), Mei Cui (Author), Lan Tan (Author), Qiang Dong (Author), Roman A. Zubarev (Author), Jin-Tai Yu (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The strongest risk factor of neurodegenerative diseases (NDDs) is aging. Spontaneous asparaginyl deamidation leading to formation of isoaspartate (isoAsp) has been correlated with protein aggregation in NDDs. Methods Two cohorts consisting of 140 subjects were studied. Cohort 1 c...