Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery

• Main Authors: Shahd Qassem (Author), Dor Breier (Author), Gonna Somu Naidu (Author), Inbal Hazan-Halevy (Author), Dan Peer (Author)
• Format: Knjiga
• Izdano: Elsevier, 2024-06-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Locked nucleic acids (LNAs) are a subtype of antisense oligonucleotides (ASOs) that are characterized by a bridge within the sugar moiety. LNAs owe their robustness to this chemical modification, which as the name suggests, locks it in one conformation. This perspective includes two components: a ge...