Chronic d-serine supplementation impairs insulin secretion

• Main Authors: Lisa Suwandhi (Author), Simone Hausmann (Author), Alexander Braun (Author), Tim Gruber (Author), Silke S. Heinzmann (Author), Eric J.C. Gálvez (Author), Achim Buck (Author), Beata Legutko (Author), Andreas Israel (Author), Annette Feuchtinger (Author), Elizabeth Haythorne (Author), Harald Staiger (Author), Martin Heni (Author), Hans-Ulrich Häring (Author), Philippe Schmitt-Kopplin (Author), Axel Walch (Author), Cristina García Cáceres (Author), Matthias H. Tschöp (Author), Guy A. Rutter (Author), Till Strowig (Author), Martin Elsner (Author), Siegfried Ussar (Author)
• Format: Bog
• Udgivet: Elsevier, 2018-10-01T00:00:00Z.
• Fag: article
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Objective: The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of pancreatic NMDA receptors as well as loss of the d-serine producing enzyme serine racemase have been shown to modulate insulin secretion. Thus, we aim to study the...