A synthetic peptide from Sipunculus nudus promotes bone formation via Estrogen/MAPK signal pathway based on network pharmacology

• Main Authors: Peiran Wang (Author), Zhenhui Feng (Author), Siyu Chen (Author), Yingye Liang (Author), Haiyan Hou (Author), Qianqian Ouyang (Author), Hui Yu (Author), Hua Ye (Author), Lei Cai (Author), Yi Qi (Author), Kefeng Wu (Author), Hui Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tripeptide Leu-Pro-Lys (LPK), derived from the Sipunculus nudus protein, was synthesized and studied to investigate its potential protective effect on bone formation. The effect and mechanism of LPK were analyzed through network pharmacology, bioinformatics, and experimental pharmacology. The st...