Thermoreversible Gel-Loaded Amphotericin B for the Treatment of Dermal and Vaginal Candidiasis

• Main Authors: Lilian Sosa (Author), Ana Cristina Calpena (Author), Marcelle Silva-Abreu (Author), Lupe Carolina Espinoza (Author), María Rincón (Author), Nuria Bozal (Author), Oscar Domenech (Author), María José Rodríguez-Lagunas (Author), Beatriz Clares (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was designed to develop a thermoreversible gel of Pluronic (P407) loaded amphotericin B (AmB-gel) for the dermal and vaginal treatment of candidiasis. P407 was used as a copolymer to exploit potential advantages related to increasing drug concentration in the tissue layer in order...