Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis

• Main Authors: Muthu K. Shanmugam (Author), Kwang Seok Ahn (Author), Annie Hsu (Author), Chern Chiuh Woo (Author), Yi Yuan (Author), Kwong Huat Benny Tan (Author), Arunachalam Chinnathambi (Author), Tahani Awad Alahmadi (Author), Sulaiman Ali Alharbi (Author), Angele Pei Fern Koh (Author), Frank Arfuso (Author), Ruby Yun-Ju Huang (Author), Lina H. K. Lim (Author), Gautam Sethi (Author), Alan Prem Kumar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in patients with breast cancer. Therefore, new agents that can abrogate CXCR4 expression have potential against breast canc...