Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal-fetal inflammation in mice

• Main Authors: Jose Galaz (Author), Roberto Romero (Author), Marcia Arenas-Hernandez (Author), Marcelo Farias-Jofre (Author), Kenichiro Motomura (Author), Zhenjie Liu (Author), Naoki Kawahara (Author), Catherine Demery-Poulos (Author), Tzu Ning Liu (Author), Justin Padron (Author), Bogdan Panaitescu (Author), Nardhy Gomez-Lopez (Author)
• Format: Book
• Published: BMC, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background One of every four preterm neonates is born to a woman with sterile intra-amniotic inflammation (inflammatory process induced by alarmins); yet, this clinical condition still lacks treatment. Herein, we utilized an established murine model of sterile intra-amniotic inflammation in...