Design, synthesis, and cytotoxic activities of isaindigotone derivatives as potential anti-gastric cancer agents

• Main Authors: Kangjia Du (Author), Wantong Ma (Author), Chengjie Yang (Author), Zhongkun Zhou (Author), Shujian Hu (Author), Yanan Tian (Author), Hao Zhang (Author), Yunhao Ma (Author), Xinrong Jiang (Author), Hongmei Zhu (Author), Huanxiang Liu (Author), Peng Chen (Author), Yingqian Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel derivatives of isaindigotone, which comes from the root of isaits indinatca Fort, were synthesised (Compound 1-26). Four human gastrointestinal cancer cells (HCT116, PANC-1, SMMC-7721, and AGS) were employed to evaluate the anti-proliferative activity. Among them, Compound 6 displa...