Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate-Sensitized Rats

• Main Authors: Hiroyuki Mizuguchi (Author), Masaya Hatano (Author), Chiyo Matsushita (Author), Hayato Umehara (Author), Wakana Kuroda (Author), Yoshiyuki Kitamura (Author), Noriaki Takeda (Author), Hiroyuki Fukui (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antihistamines are effective for treatment of seasonal nasal allergy. Recently, prophylactic treatment with antihistamines in patients with pollinosis was reported to be more effective when started before the pollen season. The administration with antihistamines from 2 to 6 weeks before onset of the...