MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma

• Main Authors: Shouhua Zhang (Author), Hongyan Xu (Author), Weiming Li (Author), Jianfeng Ji (Author), Qifang Jin (Author), Leifeng Chen (Author), Qiang Gan (Author), Qiang Tao (Author), Yong Chai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia is an important tumor feature and hypoxia-inducible factor 1 (HIF-1) is a master regulator of cell response to hypoxia. Mouse double minute 2 homolog (MDM2) promotes cancer cell survival in retinoblastoma (RB), with the underlying mechanism remaining elusive. In this study, we investigated t...