Machine-Learning Guided Discovery of Bioactive Inhibitors of PD1-PDL1 Interaction

• Auteurs principaux: Sachin P. Patil (Auteur), Elena Fattakhova (Auteur), Jeremy Hofer (Auteur), Michael Oravic (Auteur), Autumn Bender (Auteur), Jason Brearey (Auteur), Daniel Parker (Auteur), Madison Radnoff (Auteur), Zackary Smith (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The selective activation of the innate immune system through blockade of immune checkpoint PD1-PDL1 interaction has proven effective against a variety of cancers. In contrast to six antibody therapies approved and several under clinical investigation, the development of small-molecule PD1-PDL1 inhib...