Machine-Learning Guided Discovery of Bioactive Inhibitors of PD1-PDL1 Interaction

• Main Authors: Sachin P. Patil (Author), Elena Fattakhova (Author), Jeremy Hofer (Author), Michael Oravic (Author), Autumn Bender (Author), Jason Brearey (Author), Daniel Parker (Author), Madison Radnoff (Author), Zackary Smith (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The selective activation of the innate immune system through blockade of immune checkpoint PD1-PDL1 interaction has proven effective against a variety of cancers. In contrast to six antibody therapies approved and several under clinical investigation, the development of small-molecule PD1-PDL1 inhib...