Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers

• Main Authors: Janak R. Wedagedera (Author), Anthonia Afuape (Author), Siri Kalyan Chirumamilla (Author), Hiroshi Momiji (Author), Robert Leary (Author), Mike Dunlavey (Author), Richard Matthews (Author), Khaled Abduljalil (Author), Masoud Jamei (Author), Frederic Y. Bois (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Physiologically‐based pharmacokinetic (PBPK) models usually include a large number of parameters whose values are obtained using in vitro to in vivo extrapolation. However, such extrapolations can be uncertain and may benefit from inclusion of evidence from clinical observations via paramet...