Progress in Allergy Signal Research on Mast Cells: The Role of Histamine in Goblet Cell Hyperplasia in Allergic Airway Inflammation -a Study Using the Hdc Knockout Mouse

• Main Authors: Kohei Yamauchi (Author), Hong Mei Piao (Author), Toshihide Nakadate (Author), Toshiki Shikanai (Author), Yutaka Nakamura (Author), Miyuki Niisato (Author), Harumasa Ito (Author), Takashi Mouri (Author), Hitoshi Kobayashi (Author), Chihaya Maesawa (Author), Takashi Sawai (Author), Hiroshi Ohtsu (Author), Hiroshi Inoue (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although histamine is a central mediator in the immediate allergic reaction, its role in goblet cell hyperplasia in the airway of asthma is not completely understood. This study was designed to examine the role of histamine in goblet cell hyperplasia using histamine-deficient mice (Hdc −/−mice) with...