Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection

• Hauptverfasser: Kendall Free (Verfasst von), Hideyuki Nakanishi (Verfasst von), Keiji Itaka (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2023-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

For the selective elimination of deleterious cells (e.g., cancer cells and virus-infected cells), the use of a cytotoxic gene is a promising approach. DNA-based systems have achieved selective cell elimination but risk insertional mutagenesis. Here, we developed a synthetic mRNA-based system to sele...