Targeted Alpha Therapy: All We Need to Know about ²²⁵Ac's Physical Characteristics and Production as a Potential Theranostic Radionuclide

• Main Authors: Wael Jalloul (Author), Vlad Ghizdovat (Author), Cati Raluca Stolniceanu (Author), Teodor Ionescu (Author), Irena Cristina Grierosu (Author), Ioana Pavaleanu (Author), Mihaela Moscalu (Author), Cipriana Stefanescu (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The high energy of α emitters, and the strong linear energy transfer that goes along with it, lead to very efficient cell killing through DNA damage. Moreover, the degree of oxygenation and the cell cycle state have no impact on these effects. Therefore, α radioisotopes can offer a treatment choice...