Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in non-small cell lung cancer

• Main Authors: Chenxue Mao (Author), Juan Chen (Author), Ting Zou (Author), Yuankang Zhou (Author), Junyan Liu (Author), Xi Li (Author), Xiangping Li (Author), Min Li (Author), Pinhua Pan (Author), Wei Zhuo (Author), Yang Gao (Author), Shuo Hu (Author), Desheng Xiao (Author), Lin Wu (Author), Zhan Wang (Author), Heng Xu (Author), Wen Yang (Author), Yingjie Xu (Author), Haihua Xiao (Author), Kazuhiko Hanada (Author), Wei Zhang (Author), Honghao Zhou (Author), Jiye Yin (Author), Zhaoqian Liu (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To explore the pharmacogenomic markers that affect the platinum-based chemotherapy response in non-small-cell lung carcinoma (NSCLC), we performed a two-cohort of genome-wide association studies (GWAS), including 34 for WES-based and 433 for microarray-based analyses, as well as two independent vali...