Short divalent ethacrynic amides as pro-inhibitors of glutathione S-transferase isozyme Mu and potent sensitisers of cisplatin-resistant ovarian cancers

• Главные авторы: Bangtian Xu (Автор), Tingting Tong (Автор), Xin Wang (Автор), Fang Liu (Автор), Xiang Zhang (Автор), Xiaolei Hu (Автор), Xinpeng Li (Автор), Xiaolan Yang (Автор), Fei Liao (Автор)
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• Опубликовано: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Предметы: article
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The linking of ethacrynic acid with ethylenediamine and 1,4-butanediamine gave EDEA and BDEA, respectively, as membrane-permeable divalent pro-inhibitors of glutathione S-transferase (GST). Their divalent glutathione conjugates showed subnanomolar inhibition and divalence-binding to GSTmu (GSTM) (PD...