Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice

• Main Authors: Jongkil Kim (Author), Kunho Chung (Author), Changseon Choi (Author), Jagadish Beloor (Author), Irfan Ullah (Author), Nahyeon Kim (Author), Kuen Yong Lee (Author), Sang-Kyung Lee (Author), Priti Kumar (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adipose tissue macrophage (ATM)-mediated inflammation is a key feature contributing to the adverse metabolic outcomes of dietary obesity. Recruitment of macrophages to obese adipose tissues (AT) can occur through the engagement of CCR2, the receptor for MCP-1 (monocyte chemoattractant protein-1), wh...