KCNJ15 deficiency promotes drug resistance via affecting the function of lysosomes

• Main Authors: Xinbo Qiao (Author), Yixiao Zhang (Author), Zhan Zhang (Author), Nan Niu (Author), Haonan Li (Author), Lisha Sun (Author), Qingtian Ma (Author), Jiawen Bu (Author), Jinchi Liu (Author), Guanglei Chen (Author), Jinqi Xue (Author), Yongliang Yang (Author), Caigang Liu (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The altered lysosomal function can induce drug redistribution which leads to drug resistance and poor prognosis for cancer patients. V-ATPase, an ATP-driven proton pump positioned at lysosomal surfaces, is responsible for maintaining the stability of lysosome. Herein, we reported that the potassium...