Immune escape and immune camouflage may reduce the efficacy of RTS,S vaccine in Malawi

• Main Authors: Sundos Khan (Author), Matthew Parrillo (Author), Andres H. Gutierrez (Author), Frances E. Terry (Author), Leonard Moise (Author), William D. Martin (Author), Anne S. De Groot (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The RTS,S/AS01 malaria vaccine will undergo a pilot vaccination study in sub-Saharan Africa beginning in 2019. RTS,S/AS01 Phase III trials reported an efficacy of 28.3% (children 5-17 months) and 18.3% (infants 6-12 weeks), with substantial variability across study sites. We postulated that the rela...