Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection

• Main Authors: Sophie Seang (Author), Anoma Somasunderam (Author), Maitreyee Nigalye (Author), Ma Somsouk (Author), Timoty W. Schacker (Author), Joyce L. Sanchez (Author), Peter W. Hunt (Author), Netanya S. Utay (Author), Jordan E. Lake (Author)
• Format: Book
• Published: Case Western Reserve University, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Incomplete immune reconstitution may occur despite successful antiretroviral therapy (ART). Gut-associated lymphoid tissue (GALT) fibrosis may contribute via local CD4+ T lymphocyte depletion, intestinal barrier disruption, microbial translocation, and immune activation. Methods: In a cr...